Five Nigeria internationals are set to feature in Saturday’s London derbies, while Tolu Arokodare is poised for his first Premier League home appearance as Wolverhampton Wanderers host Leeds United at Molineux.
The headline act sees Christantus Uche’s Crystal Palace travel to face West Ham United at the London Stadium, where the 22-year-old midfielder will be looking to secure his first Premier League start after making two substitute appearances since his deadline day loan move from Getafe.
The match could be crucial to triggering a permanent move to Palace, with his loan deal containing a mandatory purchase clause if he starts at least 10 matches this season.
Across West London, Fulham’s Nigerian trio of Alex Iwobi, Calvin Bassey and Samuel Chukwueze will take on Brentford’s Frank Onyeka at Craven Cottage in another mouth-watering London derby.
Chukwueze will be hoping to make the squad after being absent from the team sheet during Fulham’s dramatic 1-0 victory over Leeds United last weekend, where Gabriel Gudmundsson’s stoppage-time own goal secured the Cottagers’ first Premier League win of the season.
Iwobi and Bassey both started that match, with the defender playing the full 90 minutes while the midfielder was substituted in the 76th minute.
At Molineux, Arokodare will be eager to help Wolves claim their first points of the campaign when they host Leeds United, having made his Premier League debut in last weekend’s 1-0 defeat at Newcastle United.
The Nigerian striker came close to marking his debut with a goal, nearly tapping home at the back post before Newcastle’s Fabian Schar made a last-ditch tackle to deny him.
Wolves have endured a nightmare start to the season, losing each of their opening four games for the first time in their 127-season history in the Football League or Premier League, leaving them rooted to the bottom of the table.
Palace head into their clash with West Ham on an excellent run, remaining unbeaten in their last 10 games and sitting eighth in the Premier League table after collecting six points from their opening four fixtures.
The Eagles have been defensively solid this season, conceding just once in the league and only twice across seven competitive matches following the summer departure of star attacker Eberechi Eze to Arsenal.
Palace boast an excellent recent record at the London Stadium, remaining unbeaten in their last six visits to West Ham, including a 2-0 victory in January courtesy of a Jean-Philippe Mateta brace.
Fulham, meanwhile, will be looking to build on their fortunate victory over Leeds when they welcome Brentford to Craven Cottage in what promises to be another captivating West London affair.
The Cottagers completed a Premier League double over the Bees last season and will attempt to win three league matches in a row against Brentford for just the second time since winning their first three encounters from 1928 to 1929.